Determination of proteomics and signal transduction pathways of primary LECs compared to primary BECs from different sources. LC-MS/MS analysis of proteins specifically expressed in LECs vs. BECs, bioinformatics analysis. Validation and functional analyses using immunohistochemistry, siRNA and genetic models. MS-identification of attached glycans/ubiquitination.

 

 

Participating consortium partners:

 

® Dr. Kari Alitalo, University of Helsinki, Finland

® Dr. Hellmut Augustin, German Cancer Research Center, Heidelberg, Germany

® Dr. Gerhard Christofori, University of Basel, Switzerland

® Dr. Lena Claesson-Welsh, Uppsala University, Sweden

® Dr. Anne Eichmann, Institut National de la Sante et de la Recherche Medicale, Paris, France