Lymphangiogenomics

 

 
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Work Package 3:

Molecular mechanisms and therapeutic potential of

progenitor cells in lymphangiogenesis

 

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Last Update: February 20, 2008

 

 

 

 

 

  

 

 

 

Circulating endothelial progenitor cells (EPCs) have been shown to participate in postnatal angiogenic processes. The purpose is to determine wether circulating EPC "lymphangioblasts" contribute to lymphangiogenic processes and to analyze LEC differentiation from human and murine embryonic stem (h/mES) cells. Mechanisms of intrinsic and gene-manipulated BEC and LEC differentiation from h/mES cells and from EPCs is being analyzed. A marker tracing approach as well as a systems biology approach is being employed. EPC participation in lymphangiogenesis is being analzyed. The potential of mutipotent adult progenitor cells (MAPCs) to differentiate into lymphatic endothelial cells in vitro and in vivo is being assed.

 

 

Participating consortium partners:

 

® Dr. Kari Alitalo, University of Helsinki, Finland

® Dr. Hellmut Augustin, German Cancer Research Center,Heidelberg, Germany

® Dr. Peter Carmeliet, Flancers Interuniversity Institute for Biotechnology, Leuven, Belgium

® Dr. Elisabetta Dejana, IFOM Fondazione Istituto FIRC di Oncologia Moleculare, Milan, Italy

® Dr. Dontscho Kerjaschki, Medical University of Vienna, Austria

® Dr. Seppo Ylä-Herttuala, University of Kuopio, Finland