Lymphangiogenomics

 

 
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Signal transduction directed by VEGF receptors,

in vitro and in vivo

 

 

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Last Update: April 28, 2008

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

  

 

 

 

  

 

 

 

 

Our group at the Department of Genetics and Pathology at Uppsala University is engaged in projects concerning regulation of endothelial cell function. Our contribution to the network is primarily on signal transduction by VEGF receptors. We have determined sites of tyrosine phosphorylation in the three VEGF receptors. We are currently working on the relevance of these sites in vivo, in physiological and pathological processes, and their roles in critical signal transduction events in blood and lymphendothelial cell responses to VEGF family members. We are furthermore interested in the role of VEGF receptor heterodimerization and have shown that heterodimerization occurs between VEGFR-2 and -3.

 

 

Responsible for this project:

 

 

Dr. Lena Claesson-Welsh

Dept. of Genetics and Pathology

The Rudbeck Laboratory

Uppsala University

Dag Hammarskjöldsv. 20

75185 Uppsala, Sweden

Phone: +46 18 4714363

Fax: +46 18 558931

E-mail: lena.welsh(at)genpat.uu.se

 

 

Selected recent publications:

  1. Kawamura H, Li X, Goishi K, Jakobsson L, van Meeteren L., Cebe Suarez S, , Shimizu A, Edholm D, Ballmer-Hofer K, Kjellen L, Klagsbrun M, Claesson-Welsh L. Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization. Blood, under revision.
     

  2. Jakobsson L, Kreuger J, Claesson-Welsh L. Building blood vessels--stem cell models in vascular biology. J Cell Biol. 177(5):751-5, 2007
     

  3. Nilsson I, Rolny C, Wu Y, Pytowski B, Hicklin D, Alitalo K, Claesson-Welsh L and Wennstrom S. Vascular endothelial growth factor receptor-3 in hypoxia-induced vascular development. Faseb J. 18:1507-1515, 2004.
     

  4. Holmqvist K, Cross MJ, Rolny C, Hagerkvist R, Rahimi N, Matsumoto T, Claesson-Welsh L, Welsh M. The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration. J Biol Chem 279:22267-75, 2004.
     

  5. Magnusson P, Rolny C, Jakobsson L, Wikner C, Wu Y, Hicklin DJ, Claesson-Welsh L. Deregulation of Flk-1/vascular endothelial growth factor receptor-2 in fibroblast growth factor receptor-1-deficient vascular stem cell development. J Cell Sci 117:1513-23, 2004.
     

  6. Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L. VEGF-receptor signal transduction. Trends Biochem Sci 28:488-94, 2003.
     

  7. Dixelius J, Makinen T, Wirzenius M, Karkkainen MJ, Wernstedt C, Alitalo K, Claesson-Welsh L. Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3). heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites. J Biol Chem 278:40973-9, 2003.
     

  8. Matsumoto T, Turesson I, Book M, Gerwins P, Claesson-Welsh L. p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis. J Cell Biol 156:149-60, 2002.
     

  9. Matsumoto T, Claesson-Welsh L. VEGF receptor signal transduction. Sci STKE 112:RE21, 2001. Review.
     

  10. Ito N, Huang K, Claesson-Welsh L. Signal transduction by VEGF receptor-1 wild type and mutant proteins. Cell Signal 13:849-54, 2001.
     

  11. Huang K, Andersson C, Roomans GM, Ito N, Claesson-Welsh L. Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers. Int J Biochem Cell Biol 33:315-24, 2001.
     

  12. Cross MJ, Claesson-Welsh L. FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition. Trends Pharmacol Sci 22:201-7, 2001.
     

  13. Qi JH, Claesson-Welsh L. VEGF-induced activation of phosphoinositide 3-kinase is dependent on focal adhesion kinase. Exp Cell Res 263:173-82, 2001.