Lymphangiogenomics

 

 
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Role of neural genes in lymphangiogenesis

 

 

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Last Update: June 23, 2009

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

  

 

 

 

  

 

 

The vascular and the nervous systems show striking anatomical similarities. Both nerves and blood vessels ramify throughout nearly all domains of the body. Analogous to arterial and venous blood flow, the directionality of information flow in the nervous system is controlled by subdivisions into motor and sensory pathways. Like blood vessels with their mural and ECs, the nerves comprise two intimately associated cell types, neurons and glial cells. In addition to these morphological features, it has been recently discovered that the development of the vascular and nervous system is controlled by common molecular mechanisms. Among the genes controlling neural as well as vascular development, our group has shown arterial-specific expression of the NRP-1 receptor and selective expression of NRP-2 in veins and lymphatic vessels. The growth of lymphatic vessels is perturbed in NRP-2-deficient mice. We have recently examined the expression of other molecules known to be involved in neural development in the vascular system and our results suggest to study other neural genes emerging from the bioinformatics analysis.

 

 

Responsible for the project:

 

 

Dr. Anne Eichmann

INSERM U833

11 Place Marcelin Berthelot

75005 Paris, France

Phone: +33 1 4427 1693

Fax: +33 1 4427 1691

E-mail: anne.eichmann(at)college-de-france.fr

 

 

Selected recent publications:

  1. Larrivée B, Freitas C, Suchting S, Brunet I, Eichmann A.Guidance of vascular development: lessons from the nervous system. Circ Res. 27;104(4):428-41, 2009.
     
  2. Jones EA, Yuan L, Breant C, Watts RJ, Eichmann A. Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos. Development.;135(14):2479-88, 2008.
     

  3. Larrivée, B., Freitas, C., Trombe, M., Lv, X., Delafarge, B., Yuan, L., Bouvrée, K., Bréant, C., Del Toro, R., Bréchot, N., Germain, S., Bono, F., Dol, F., Claes, F., Fischer, C., Autiero, M., Thomas, J.L., Carmeliet, P., Tessier-Lavigne, M., Eichmann, A. Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes&Dev. 21, 2433-47, 2007.
     

  4. Suzuki Y, Komi Y, Ashino H, Yamashita J, Inoue J, Yoshiki A, Eichmann A, Amanuma H, Kojima S. Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of Tie2 signaling in vascular progenitor cells. Blood 104:166-169, 2004.
     

  5. Tournaire R, Simon MP, le Noble F, Eichmann A, England P, Pouyssegur J. A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor. EMBO Rep 5:262-267, 2004.
     

  6. Le Noble F, Moyon D, Pardanaud L, Yuan L, Djonov V, Matthijsen R, Breant C, Fleury V, Eichmann A. Flow regulates arterial-venous differentiation in the chick embryo yolk sac. Development 131:361-375, 2004.
     

  7. Jilani SM, Murphy TJ, Thai SN, Eichmann A, Alva JA, Iruela-Arispe ML. Selective binding of lectins to embryonic chicken vasculature. J Histochem Cytochem 51:597-604, 2003.
     

  8. Yuan L, Moyon D, Pardanaud L, Breant C, Karkkainen MJ, Alitalo K, Eichmann A. Abnormal lymphatic vessel development in neuropilin 2 mutant mice. Development 129:4797-4806, 2002.
     

  9. Caprioli A, Minko K, Drevon C, Eichmann A, Dieterlen-Lievre F, Jaffredo T. Hemangioblast commitment in the avian allantois: cellular and molecular aspects. Dev Biol 238:64-78, 2001.
     

  10. Papoutsi M, Tomarev SI, Eichmann A, Prols F, Christ B, Wilting J. Endogenous origin of the lymphatics in the avian chorioallantoic membrane. Dev Dyn. Oct;222(2):238-51, 2001.
     

  11. Wilting J, Papoutsi M, Othman-Hassan K, Rodriguez-Niedenfuhr M, Prols F, Tomarev SI, Eichmann A. Development of the avian lymphatic system. Microsc Res Tech 55:81-91, 2001.
     

  12. Karkkainen MJ, Saaristo A, Jussila L, Karila KA, Lawrence EC, Pajusola K, Bueler H, Eichmann A, Kauppinen R, Kettunen MI, Yla-Herttuala S, Finegold DN, Ferrell RE, Alitalo K. A model for gene therapy of human hereditary lymphedema. Proc Natl Acad Sci USA 98:12677-12682, 2001.
     

  13. Moyon D, Pardanaud L, Yuan L, Breant C, Eichmann A. Plasticity of endothelial cells during arterial-venous differentiation in the avian embryo. Development 128:3359-3370, 2001.
     

  14. Moyon D, Pardanaud L, Yuan L, Breant C, Eichmann A. Selective expression of angiopoietin 1 and 2 in mesenchymal cells surrounding veins and arteries of the avian embryo. Mech Dev 106:133-136, 2001.
     

  15. Eichmann A, Yuan L, Breant C, Alitalo K, Koskinen PJ. Developmental expression of pim kinases suggests functions also outside of the hematopoietic system. Oncogene 19:1215-1224, 2000.
     

Reviews:

  1. Wilting J, Christ B, Yuan L, Eichmann A. Cellular and molecular mechanisms of embryonic haemangiogenesis and lymphangiogenesis. Naturwissenschaften 90:433-448, 2003.
     

  2. Eichmann A, Pardanaud L, Yuan L, Moyon D. Vasculogenesis and the search for the hemangioblast. J Hematother Stem Cell Res 11:207-214, 2002.